Treatment outcomes in multiple sclerosis
Deadline
Value of Scholarship
0
Level of Study
Country Tenable
Renewable
No
Treatment outcomes in multiple sclerosis

LocationUniversity of Melbourne, Department of Medicine
Discipline
App. deadlineApplications accepted year round/until filled
Funding
  • Scholarship available
EligibilityOpen to international applicants

Position Description

Title: MSBase at MelbourneBrain Centre Postgraduate Research Scholarship

Department:Medicine, Faculty of Medicine, Dentistry and Health Sciences, TheUniversity of Melbourne

Full-time PhD position commencing in2016

Primary supervisor: Dr Tomas Kalincik

Co-supervisor:Prof Helmut Butzkueven

Contact: tomas.kalincik@unimelb.edu.au

Research Scope

Theme

Modelling disease outcomes in multiple sclerosis

Synopsis

Multiplesclerosis is the most common cause of neurological disability among youngadults, with the peak of onset in 3-4th decades of life. Almost half of thepatients with multiple sclerosis ultimately develop severe limitation ofactivities of daily living and independence, and less than half of thepatients maintain employment. Immunomodulatory and immunosuppressantdisease modifying therapies represent the standard of disease management inpatients with relapsing multiple sclerosis. However management ofprogressive multiple sclerosis, prediction of disease outcomes andindividually-tailored therapy still remain to be resolved.

Thispostgraduate research scholarship will utilise a global observationalcohort study and statistical modelling, including analysis of longitudinaldata, propensity score-based methods and individual predictive analysis, toaddress the questions of (i) treatment and outcomes of progressive multiplesclerosis, (ii) early predictive markers of treatment response, and (iii)the outcomes of various management decisions and treatment pathways.

Outcomes and impact

The researchcompleted in the course of the candidature will inform clinical practice ofmultiple sclerosis management globally. It will further our understandingof predictors of treatment response and will enable individualised multiplesclerosis therapy. The student will develop knowledge observationalclinical research, multivariable modelling, analysis of longitudinal data,neuroepidemiology and multiple sclerosis - disease and treatmentoutcomes.

ResearchEnvironment

MSBase is a large, international,observational multiple sclerosis registry, collecting longitudinal clinicalinformation from over 37,000 patients in 119 centres and 35 countries. Itis a collaborative research initiative with a significant scientific outputgenerated over the past five years.

The Melbourne Brain Centre atRoyal Melbourne Hospital is an internationally recognised centre forclinical multiple sclerosis research, including investigator-drivenmultiple sclerosis

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